PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)c4ccc(Nc5ccccc5)cc4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001310

FormulaC26H21N3O4

Molecular weight439.471

InChIKeyZCKRFFYOFQWYRF-UHFFFAOYSA-N

Physicochemical properties

Exact mass439.1532

RDKit cLogP3.42

TPSA95.6

HBD / HBA2 / 5

Rotatable bonds5

Heavy atoms33

Hetero atoms7

Rings / aromatic5 / 3

Fraction Csp30.15

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A015555	PGDB_C001310	PGDB_AS001994	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A021779	PGDB_C001310	PGDB_AS000601	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MM.1S	WO2025110699A1	PGDB_A028323	PGDB_C001310	PGDB_AS002497	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A032487	PGDB_C001310	PGDB_AS001008	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A037179	PGDB_C001310	PGDB_AS000026	View
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A044451	PGDB_C001310	PGDB_AS001067	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A051061	PGDB_C001310	PGDB_AS001448	View
GI50	-	=	0.1-1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A053865	PGDB_C001310	PGDB_AS000013	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MV-4-11	WO2025110699A1	PGDB_A057505	PGDB_C001310	PGDB_AS002004	View
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A060193	PGDB_C001310	PGDB_AS002288	View
GI50	-	=	0.1-1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A065136	PGDB_C001310	PGDB_AS001887	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A072364	PGDB_C001310	PGDB_AS001966	View

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