PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)c4n[nH]c5ccccc45)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001312

FormulaC21H16N4O4

Molecular weight388.383

InChIKeySJRCFANAFMNIDE-UHFFFAOYSA-N

Physicochemical properties

Exact mass388.1172

RDKit cLogP1.55

TPSA112.2

HBD / HBA2 / 5

Rotatable bonds3

Heavy atoms29

Hetero atoms8

Rings / aromatic5 / 3

Fraction Csp30.19

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A007582	PGDB_C001312	PGDB_AS000026	View
GI50	-	=	0.1-1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A008601	PGDB_C001312	PGDB_AS001887	View
% Degradation	-	=	50-70	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A020051	PGDB_C001312	PGDB_AS002288	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MV-4-11	WO2025110699A1	PGDB_A032786	PGDB_C001312	PGDB_AS002004	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A041216	PGDB_C001312	PGDB_AS001966	View
% Degradation	-	=	70-90	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A048461	PGDB_C001312	PGDB_AS001994	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MM.1S	WO2025110699A1	PGDB_A056325	PGDB_C001312	PGDB_AS002497	View
% Degradation	-	=	70-90	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A059037	PGDB_C001312	PGDB_AS001008	View
% Degradation	-	=	70-90	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A059407	PGDB_C001312	PGDB_AS001448	View
% Degradation	-	=	70-90	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A061657	PGDB_C001312	PGDB_AS000601	View
% Degradation	-	=	50-70	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A069037	PGDB_C001312	PGDB_AS001067	View
GI50	-	=	0.1-1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A071552	PGDB_C001312	PGDB_AS000013	View

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