PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)c4ccc5cn[nH]c5c4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001313

FormulaC21H16N4O4

Molecular weight388.383

InChIKeyKSKJZCHYBYBLSD-UHFFFAOYSA-N

Physicochemical properties

Exact mass388.1172

RDKit cLogP1.55

TPSA112.2

HBD / HBA2 / 5

Rotatable bonds3

Heavy atoms29

Hetero atoms8

Rings / aromatic5 / 3

Fraction Csp30.19

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A008470	PGDB_C001313	PGDB_AS002288	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A017992	PGDB_C001313	PGDB_AS000026	View
GI50	-	=	0.1-1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A030182	PGDB_C001313	PGDB_AS000013	View
GI50	-	=	1-10	uM	-	—	GSPT1	-	MM.1S	WO2025110699A1	PGDB_A032092	PGDB_C001313	PGDB_AS002497	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A034870	PGDB_C001313	PGDB_AS000601	View
GI50	-	<=	10	uM	-	—	GSPT1	-	MV-4-11	WO2025110699A1	PGDB_A036001	PGDB_C001313	PGDB_AS002004	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A044853	PGDB_C001313	PGDB_AS001966	View
GI50	-	=	0.1-1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A051239	PGDB_C001313	PGDB_AS001887	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A054006	PGDB_C001313	PGDB_AS001994	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A058789	PGDB_C001313	PGDB_AS001008	View
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A061790	PGDB_C001313	PGDB_AS001067	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A069355	PGDB_C001313	PGDB_AS001448	View

Rows per pagePage 1 of 1 · 12 recordsGo to page