PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CNc1ccc2cc(C(=O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)[nH]c2c1

Compound summary

Compound IDPGDB_C001314

FormulaC23H20N4O4

Molecular weight416.437

InChIKeyXRJLIJHUCCXMML-UHFFFAOYSA-N

Physicochemical properties

Exact mass416.1485

RDKit cLogP2.2

TPSA111.4

HBD / HBA3 / 5

Rotatable bonds4

Heavy atoms31

Hetero atoms8

Rings / aromatic5 / 3

Fraction Csp30.22

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
GI50	-	<=	0.1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A010647	PGDB_C001314	PGDB_AS000013	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A011063	PGDB_C001314	PGDB_AS001966	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MV-4-11	WO2025110699A1	PGDB_A012795	PGDB_C001314	PGDB_AS002004	View
% Degradation	-	=	90-100	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A020517	PGDB_C001314	PGDB_AS001067	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MM.1S	WO2025110699A1	PGDB_A035479	PGDB_C001314	PGDB_AS002497	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A036555	PGDB_C001314	PGDB_AS000026	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A046923	PGDB_C001314	PGDB_AS001994	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A050437	PGDB_C001314	PGDB_AS001008	View
% Degradation	-	=	90-100	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A061133	PGDB_C001314	PGDB_AS002288	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A062261	PGDB_C001314	PGDB_AS000601	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A066731	PGDB_C001314	PGDB_AS001887	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A070917	PGDB_C001314	PGDB_AS001448	View

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