PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)c4ccc(-c5ccccc5)[nH]4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001319

FormulaC24H19N3O4

Molecular weight413.433

InChIKeyKPLJWKLIJTYLSK-UHFFFAOYSA-N

Physicochemical properties

Exact mass413.1376

RDKit cLogP2.67

TPSA99.3

HBD / HBA2 / 4

Rotatable bonds4

Heavy atoms31

Hetero atoms7

Rings / aromatic5 / 3

Fraction Csp30.17

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
GI50	-	=	0.1-1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A015144	PGDB_C001319	PGDB_AS000013	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A022950	PGDB_C001319	PGDB_AS001448	View
GI50	-	=	0.1-1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A026234	PGDB_C001319	PGDB_AS001887	View
Relative binding	Ctrl @ 5uM	<	10	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A030128	PGDB_C001319	PGDB_AS001966	View
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A034584	PGDB_C001319	PGDB_AS002288	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A043493	PGDB_C001319	PGDB_AS000601	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A055111	PGDB_C001319	PGDB_AS001008	View
Relative binding	Ctrl @ 5uM	<	10	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A055696	PGDB_C001319	PGDB_AS000026	View
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A059920	PGDB_C001319	PGDB_AS001067	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A066288	PGDB_C001319	PGDB_AS001994	View

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