PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)c4cc(-c5ccccc5)cs4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001320

FormulaC24H18N2O4S

Molecular weight430.485

InChIKeySTOHEAORPRVHBX-UHFFFAOYSA-N

Physicochemical properties

Exact mass430.0987

RDKit cLogP3.41

TPSA83.5

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms31

Hetero atoms7

Rings / aromatic5 / 3

Fraction Csp30.17

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	70-90	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A015947	PGDB_C001320	PGDB_AS001994	View
GI50	-	=	0.1-1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A016479	PGDB_C001320	PGDB_AS001887	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A017394	PGDB_C001320	PGDB_AS001966	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A019903	PGDB_C001320	PGDB_AS000026	View
% Degradation	-	=	30-50	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A031589	PGDB_C001320	PGDB_AS001067	View
% Degradation	-	=	70-90	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A041059	PGDB_C001320	PGDB_AS001448	View
% Degradation	-	=	30-50	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A046043	PGDB_C001320	PGDB_AS002288	View
% Degradation	-	=	70-90	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A048994	PGDB_C001320	PGDB_AS000601	View
% Degradation	-	=	70-90	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A051509	PGDB_C001320	PGDB_AS001008	View
GI50	-	=	0.1-1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A063607	PGDB_C001320	PGDB_AS000013	View

Rows per pagePage 1 of 1 · 10 recordsGo to page