PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)N4Cc5cccc6cccc4c56)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001321

FormulaC25H19N3O4

Molecular weight425.444

InChIKeyLIYVENFDMNKGRQ-UHFFFAOYSA-N

Physicochemical properties

Exact mass425.1376

RDKit cLogP2.76

TPSA86.8

HBD / HBA1 / 4

Rotatable bonds2

Heavy atoms32

Hetero atoms7

Rings / aromatic6 / 3

Fraction Csp30.2

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A011515	PGDB_C001321	PGDB_AS001008	View
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A022107	PGDB_C001321	PGDB_AS001067	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MM.1S	WO2025110699A1	PGDB_A022462	PGDB_C001321	PGDB_AS002497	View
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A031387	PGDB_C001321	PGDB_AS002288	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A034450	PGDB_C001321	PGDB_AS001448	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A048988	PGDB_C001321	PGDB_AS001966	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A061171	PGDB_C001321	PGDB_AS000601	View
GI50	-	=	0.1-1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A064665	PGDB_C001321	PGDB_AS000013	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A064826	PGDB_C001321	PGDB_AS000026	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A071924	PGDB_C001321	PGDB_AS001994	View
GI50	-	=	0.1-1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A074018	PGDB_C001321	PGDB_AS001887	View

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