PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)c4cc5ccccc5o4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001322

FormulaC22H16N2O5

Molecular weight388.379

InChIKeyOCKGJBFKHMTLFG-UHFFFAOYSA-N

Physicochemical properties

Exact mass388.1059

RDKit cLogP2.42

TPSA96.7

HBD / HBA1 / 5

Rotatable bonds3

Heavy atoms29

Hetero atoms7

Rings / aromatic5 / 3

Fraction Csp30.18

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A007052	PGDB_C001322	PGDB_AS001994	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A007466	PGDB_C001322	PGDB_AS000026	View
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A014409	PGDB_C001322	PGDB_AS002288	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A034373	PGDB_C001322	PGDB_AS001966	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A035040	PGDB_C001322	PGDB_AS001448	View
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A037136	PGDB_C001322	PGDB_AS001067	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A046422	PGDB_C001322	PGDB_AS000601	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MM.1S	WO2025110699A1	PGDB_A046844	PGDB_C001322	PGDB_AS002497	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A047213	PGDB_C001322	PGDB_AS001887	View
GI50	-	<=	0.1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A063442	PGDB_C001322	PGDB_AS000013	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A076234	PGDB_C001322	PGDB_AS001008	View

Rows per pagePage 1 of 1 · 11 recordsGo to page