PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)c4cn(-c5ccccc5)c5ccccc45)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001323

FormulaC28H21N3O4

Molecular weight463.493

InChIKeyONGWDJHNJKPREX-UHFFFAOYSA-N

Physicochemical properties

Exact mass463.1532

RDKit cLogP3.62

TPSA88.5

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms35

Hetero atoms7

Rings / aromatic6 / 4

Fraction Csp30.14

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A008318	PGDB_C001323	PGDB_AS000026	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A017937	PGDB_C001323	PGDB_AS001994	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A031459	PGDB_C001323	PGDB_AS001966	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A034664	PGDB_C001323	PGDB_AS001448	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A038817	PGDB_C001323	PGDB_AS000601	View
% Degradation	-	=	90-100	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A040484	PGDB_C001323	PGDB_AS002288	View
GI50	-	<=	0.1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A043261	PGDB_C001323	PGDB_AS000013	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A045146	PGDB_C001323	PGDB_AS001008	View
% Degradation	-	=	90-100	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A055142	PGDB_C001323	PGDB_AS001067	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A072711	PGDB_C001323	PGDB_AS001887	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MM.1S	WO2025110699A1	PGDB_A075871	PGDB_C001323	PGDB_AS002497	View

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