PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)N4Cc5ccccc5C4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001324

FormulaC22H19N3O4

Molecular weight389.411

InChIKeyFIIAGEUEYRBNTL-UHFFFAOYSA-N

Physicochemical properties

Exact mass389.1376

RDKit cLogP1.6

TPSA86.8

HBD / HBA1 / 4

Rotatable bonds2

Heavy atoms29

Hetero atoms7

Rings / aromatic5 / 2

Fraction Csp30.27

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A007973	PGDB_C001324	PGDB_AS001448	View
GI50	-	<=	0.1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A019157	PGDB_C001324	PGDB_AS001887	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A021833	PGDB_C001324	PGDB_AS001008	View
% Degradation	-	=	90-100	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A025304	PGDB_C001324	PGDB_AS002288	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A034295	PGDB_C001324	PGDB_AS001994	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A037455	PGDB_C001324	PGDB_AS000601	View
GI50	-	<=	0.1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A039006	PGDB_C001324	PGDB_AS000013	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A042536	PGDB_C001324	PGDB_AS001966	View
Relative binding	Ctrl @ 5uM	<	0.1	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A074313	PGDB_C001324	PGDB_AS000026	View
% Degradation	-	=	90-100	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A076282	PGDB_C001324	PGDB_AS001067	View

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