PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)c4coc5ccccc45)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C001325

FormulaC22H16N2O5

Molecular weight388.379

InChIKeyFRYOQPGWFSMKCT-UHFFFAOYSA-N

Physicochemical properties

Exact mass388.1059

RDKit cLogP2.42

TPSA96.7

HBD / HBA1 / 5

Rotatable bonds3

Heavy atoms29

Hetero atoms7

Rings / aromatic5 / 3

Fraction Csp30.18

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
GI50	-	<=	0.1	uM	-	—	GSPT1	-	MM.1S	WO2025110699A1	PGDB_A011311	PGDB_C001325	PGDB_AS002497	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A014356	PGDB_C001325	PGDB_AS001448	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A026976	PGDB_C001325	PGDB_AS001008	View
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A033062	PGDB_C001325	PGDB_AS002288	View
GI50	-	=	0.1-1	uM	-	—	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A038381	PGDB_C001325	PGDB_AS001887	View
Relative binding	Ctrl @ 5uM	<	10	%	5 uM	1 h	CRBN	CRBN	HEK293	WO2025110699A1	PGDB_A041633	PGDB_C001325	PGDB_AS001966	View
% Degradation	-	=	90-100	%	1 uM	24 h	GSPT1	-	Jurkat	KR20250075510A	PGDB_A044621	PGDB_C001325	PGDB_AS000601	View
GI50	-	=	0.1-1	nM	-	—	GSPT1	-	Jurkat	KR20250075510A	PGDB_A054216	PGDB_C001325	PGDB_AS000013	View
% Degradation	-	=	70-90	%	0.1 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A060215	PGDB_C001325	PGDB_AS001067	View
% Degradation	-	=	90-100	%	10 uM	24 h	GSPT1	-	Jurkat	WO2025110699A1	PGDB_A062317	PGDB_C001325	PGDB_AS001994	View
Relative binding	Ctrl @ 5uM	<	10	%	5 uM	1 h	CRBN	CRBN	HEK-293	KR20250075510A	PGDB_A062889	PGDB_C001325	PGDB_AS000026	View

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