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Compound
PGDB_C006571
7 activity records1 related patents
2D structure
Cc1cccn2cc(CNc3cc(NC[C@H]4CCNC[C@@H]4O)nc4c(C(C)C)cnn34)nc12Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selectivity index | CDK7 / CDK12 | = | 5.9 | fold | - | — | - | - | - | CN114929708B | PGDB_A009464 | PGDB_C006571 | PGDB_AS002236 | View |
| IC50 | - | = | 55 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A010600 | PGDB_C006571 | PGDB_AS001066 | View |
| IC50 | - | = | 305 | nM | - | — | CDK7 | - | - | CN114929708B | PGDB_A012717 | PGDB_C006571 | PGDB_AS002150 | View |
| IC50 | - | = | 8.9 | nM | - | — | CDK12 | - | A673 | CN114929708B | PGDB_A029905 | PGDB_C006571 | PGDB_AS002202 | View |
| IC50 | - | = | 51 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A044416 | PGDB_C006571 | PGDB_AS001268 | View |
| IC50 | - | = | 12 | nM | - | — | CDK12 | - | A673 | CN114929708B | PGDB_A058733 | PGDB_C006571 | PGDB_AS002570 | View |
| IC50 | - | = | 51.7 | nM | - | — | CDK12 | - | - | CN114929708B | PGDB_A065866 | PGDB_C006571 | PGDB_AS001187 | View |