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Compound
PGDB_C031958
11 activity records1 related patents
2D structure
C[C@H](Oc1nc(-c2noc3c2CCC[C@@]32CCCc3sc(N)c(C#N)c32)nc2c1CN(CCCN1CC[C@@H](c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C(F)(F)C1)C2)[C@@H]1C[C@@H](F)CN1CCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dmax | - | = | 82 | % | - | 18 h | KRAS | - | - | WO2026114958A1 | PGDB_A002916 | PGDB_C031958 | PGDB_AS001227 | View |
| IC50 | - | = | 3.8 | nM | - | — | - | CRBN | SW620 | WO2026114958A1 | PGDB_A004068 | PGDB_C031958 | PGDB_AS001786 | View |
| DC50 | - | > | 3000 | nM | - | — | CSNK1A1 | CRBN | HEK293 | WO2026114958A1 | PGDB_A004212 | PGDB_C031958 | PGDB_AS001709 | View |
| IC50 | - | = | 102.1 | nM | - | — | - | CRBN | AsPC-1 | WO2026114958A1 | PGDB_A004356 | PGDB_C031958 | PGDB_AS000561 | View |
| IC50 | - | = | 78 | nM | - | — | CRBN | CRBN | Tni(Hi5)insect | WO2026114958A1 | PGDB_A004832 | PGDB_C031958 | PGDB_AS000132 | View |
| DC50 | - | > | 3000 | nM | - | — | GSPT1 | CRBN | HEK293 | WO2026114958A1 | PGDB_A006107 | PGDB_C031958 | PGDB_AS001690 | View |
| IC50 | - | = | 1.1 | nM | - | — | - | CRBN | SK-CO-1 | WO2026114958A1 | PGDB_A078472 | PGDB_C031958 | PGDB_AS002392 | View |
| IC50 | - | = | 3.4 | nM | - | — | KRAS | CRBN | H358 | WO2026114958A1 | PGDB_A078767 | PGDB_C031958 | PGDB_AS000990 | View |
| DC50 | - | = | 2.7 | nM | - | — | KRAS | - | - | WO2026114958A1 | PGDB_A078878 | PGDB_C031958 | PGDB_AS002526 | View |
| IC50 | - | = | 1086.3 | nM | - | — | - | CRBN | LS513 | WO2026114958A1 | PGDB_A079186 | PGDB_C031958 | PGDB_AS001452 | View |
| IC50 | - | = | 5.8 | nM | - | — | - | CRBN | LOVO | WO2026114958A1 | PGDB_A080568 | PGDB_C031958 | PGDB_AS000484 | View |