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Compound
PGDB_C001479
9 activity records4 related patents
2D structure
O=C1CCC(N2Cc3ccc(COC(=O)Nc4cc(OC(F)(F)F)ccc4F)cc3C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | > | 500 | nM | - | — | CRBN | CRBN | - | WO2024015565A1 | PGDB_A018025 | PGDB_C001479 | PGDB_AS000094 | View |
| IC50 | - | = | 25 | nM | - | — | CRBN | CRBN | NCI-H1155 | WO2024125437A1 | PGDB_A018808 | PGDB_C001479 | PGDB_AS001968 | View |
| DC50 | - | = | 8.41 | nM | - | — | GSPT1 | - | HEK293 | CN118852145A | PGDB_A032474 | PGDB_C001479 | PGDB_AS001853 | View |
| IC50 | - | = | 25 | nM | - | — | GSPT1 | - | NCI-H1155 | CN118852145A | PGDB_A038032 | PGDB_C001479 | PGDB_AS001039 | View |
| % Degradation | - | = | 25.46 | % | Concentration context: 100 nM | 6 h | GSPT1 | - | NCI-H1155 | WO2024125437A1 | PGDB_A038095 | PGDB_C001479 | PGDB_AS001010 | View |
| % Inhibition | - | = | 80.46 | % | Concentration series: 3 uM, 5 uM, 10 uM | 5 min | KCNH2 | - | HEK293 | WO2025026218A1 | PGDB_A046275 | PGDB_C001479 | PGDB_AS000603 | View |
| IC50 | - | = | 281 | nM | - | — | CRBN | CRBN | - | CN118852145A | PGDB_A056396 | PGDB_C001479 | PGDB_AS000570 | View |
| Dmax | - | = | 86.63 | % | Concentration series: 1 uM | 24 h | GSPT1 | - | HEK293 | CN118852145A | PGDB_A063990 | PGDB_C001479 | PGDB_AS002339 | View |
| % Degradation | - | = | 81.61 | % | Concentration context: 10 nM | 6 h | GSPT1 | - | NCI-H1155 | WO2024125437A1 | PGDB_A074243 | PGDB_C001479 | PGDB_AS000061 | View |