PatGlueDB | Molecular Glue Patent Bioactivity Database

Target summary

Target IDPGDB_T000011

NameKRAS

Gene symbolKRAS

Protein nameGTPase KRas

UniProt IDP01116

Rolebinding_partner | degradation_target | primary_target

Compounds643

Activity records1,754

Assays54

Patents7

Activity compounds and values

Activity records

1,754 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	71	%	-	18 h	KRAS	-	-	WO2026114958A1	PGDB_A000080	PGDB_C031947	PGDB_AS001227	View
DC50	-	=	2.9	nM	-	—	KRAS	-	-	WO2026114958A1	PGDB_A000102	PGDB_C031991	PGDB_AS002526	View
IC50	-	=	11.7	nM	-	—	KRAS	CRBN	H358	WO2026114958A1	PGDB_A000116	PGDB_C031956	PGDB_AS000990	View
IC50	-	=	14.4	nM	-	—	KRAS	CRBN	H358	WO2026114958A1	PGDB_A000124	PGDB_C031964	PGDB_AS000990	View
IC50	-	=	3.7	nM	-	—	KRAS	CRBN	H358	WO2026114958A1	PGDB_A000165	PGDB_C031967	PGDB_AS000990	View
Dmax	-	=	82	%	-	18 h	KRAS	-	-	WO2026114958A1	PGDB_A000166	PGDB_C031975	PGDB_AS001227	View
IC50	-	=	5.9	nM	-	—	KRAS	CRBN	H358	WO2026114958A1	PGDB_A000195	PGDB_C031982	PGDB_AS000990	View
Dmax	-	=	79	%	-	18 h	KRAS	-	-	WO2026114958A1	PGDB_A000212	PGDB_C031966	PGDB_AS001980	View
DC50	-	=	2	nM	-	—	KRAS	-	-	WO2026114958A1	PGDB_A000262	PGDB_C031972	PGDB_AS001045	View
DC50	-	=	3.1	nM	-	—	KRAS	-	-	WO2026114958A1	PGDB_A000381	PGDB_C031947	PGDB_AS001045	View
DC50	-	=	1.4	nM	-	—	KRAS	-	-	WO2026114958A1	PGDB_A000388	PGDB_C031991	PGDB_AS001045	View
Dmax	-	=	66	%	-	18 h	KRAS	-	-	WO2026114958A1	PGDB_A000408	PGDB_C031989	PGDB_AS001980	View
Dmax	-	=	70	%	-	18 h	KRAS	-	-	WO2026114958A1	PGDB_A000488	PGDB_C031986	PGDB_AS001227	View
IC50	-	=	2	nM	-	—	KRAS	-	-	WO2026114957A1	PGDB_A000494	PGDB_C031999	PGDB_AS000596	View
DC50	-	=	2.7	nM	-	—	KRAS	-	-	WO2026114958A1	PGDB_A000523	PGDB_C031984	PGDB_AS001045	View
DC50	-	=	3.6	nM	-	—	KRAS	-	-	WO2026114958A1	PGDB_A000531	PGDB_C031978	PGDB_AS002526	View
DC50	-	=	14.2	nM	-	—	KRAS	-	-	WO2026114958A1	PGDB_A000551	PGDB_C031966	PGDB_AS002526	View
DC50	-	=	9.8	nM	-	—	KRAS	-	-	WO2026114958A1	PGDB_A000593	PGDB_C031954	PGDB_AS002526	View
IC50	-	=	1.3	nM	-	—	KRAS	CRBN	H358	WO2026114958A1	PGDB_A000601	PGDB_C031942	PGDB_AS000990	View
Dmax	-	=	77	%	-	18 h	KRAS	-	-	WO2026114958A1	PGDB_A000696	PGDB_C031963	PGDB_AS001980	View

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