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Compound
PGDB_C011593
10 activity records1 related patents
2D structure
CCN1C(c2cc(C#Cc3cnn(C)c3)cnc2[C@H](C)OC)=C2CC(C)(C)COC(=O)[C@@H]3/C=C/2c2cc(ccc21)-c1csc(n1)C[C@H](NC(=O)[C@H]1C[C@@H]1C)C(=O)N1CC3NC1CCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 100-1000 | nM | - | — | KRAS | - | - | WO2025214350A1 | PGDB_A010959 | PGDB_C011593 | PGDB_AS000307 | View |
| IC50 | - | = | 1-10 | nM | - | — | KRAS | - | NCI-H358 | WO2025214350A1 | PGDB_A014220 | PGDB_C011593 | PGDB_AS001442 | View |
| IC50 | - | = | 10-100 | nM | - | — | KRAS | - | - | WO2025214350A1 | PGDB_A015898 | PGDB_C011593 | PGDB_AS000928 | View |
| IC50 | - | = | 10-100 | nM | - | — | KRAS | - | - | WO2025214350A1 | PGDB_A018521 | PGDB_C011593 | PGDB_AS002054 | View |
| IC50 | - | = | 10-100 | nM | - | — | - | - | AsPC-1 | WO2025214350A1 | PGDB_A030415 | PGDB_C011593 | PGDB_AS001410 | View |
| IC50 | - | = | 1-10 | nM | - | — | KRAS | - | AGS | WO2025214350A1 | PGDB_A042370 | PGDB_C011593 | PGDB_AS000218 | View |
| IC50 | - | = | 1-10 | nM | - | — | KRAS | - | SW620 | WO2025214350A1 | PGDB_A048288 | PGDB_C011593 | PGDB_AS001156 | View |
| IC50 | - | = | 10-100 | nM | - | — | KRAS | - | HPAC | WO2025214350A1 | PGDB_A052891 | PGDB_C011593 | PGDB_AS002124 | View |
| IC50 | - | = | 10-100 | nM | - | — | KRAS | - | - | WO2025214350A1 | PGDB_A058216 | PGDB_C011593 | PGDB_AS001818 | View |
| IC50 | - | = | 10-100 | nM | - | — | KRAS | - | - | WO2025214350A1 | PGDB_A058442 | PGDB_C011593 | PGDB_AS000791 | View |