PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCN(c5cccc(Cl)n5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019222

FormulaC23H24ClN5O3

Molecular weight453.93

InChIKeyCQMJNAWDZMEIQD-UHFFFAOYSA-N

Physicochemical properties

Exact mass453.1568

RDKit cLogP1.82

TPSA85.8

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms32

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.39

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	50-100	nM	-	—	IKZF3	-	MM.1R	WO2025016359A1	PGDB_A010345	PGDB_C019222	PGDB_AS001084	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	VCaP	WO2025016359A1	PGDB_A014368	PGDB_C019222	PGDB_AS000687	View
IC50	-	=	500-1000	nM	-	—	IKZF3	-	SW620	WO2025016359A1	PGDB_A019256	PGDB_C019222	PGDB_AS001811	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	CCRF-CEM	WO2025016359A1	PGDB_A031732	PGDB_C019222	PGDB_AS000461	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A033355	PGDB_C019222	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A035268	PGDB_C019222	PGDB_AS000700	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A040649	PGDB_C019222	PGDB_AS000690	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A048981	PGDB_C019222	PGDB_AS001897	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A055843	PGDB_C019222	PGDB_AS000262	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A058270	PGDB_C019222	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A058397	PGDB_C019222	PGDB_AS001760	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A059315	PGDB_C019222	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A069497	PGDB_C019222	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A069865	PGDB_C019222	PGDB_AS002465	View

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