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Compound
PGDB_C019545
10 activity records2 related patents
2D structure
Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=OCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DC50 | - | > | 10000 | nM | - | — | GSPT1 | - | HEK293 | IL323841A | PGDB_A013017 | PGDB_C019545 | PGDB_AS000381 | View |
| IC50 | - | = | 393 | nM | - | — | GSPT1 | - | HL-60 | IL323841A | PGDB_A015194 | PGDB_C019545 | PGDB_AS000799 | View |
| EC50 | - | = | 506 | nM | - | — | GSPT1 | - | HEK293 | IL323841A | PGDB_A032802 | PGDB_C019545 | PGDB_AS002492 | View |
| IC50 | - | = | 114 | nM | - | — | GSPT1 | - | NCI-H1155 | IL323841A | PGDB_A035998 | PGDB_C019545 | PGDB_AS000925 | View |
| IC50 | - | < | 1 | uM | - | — | CRBN | CRBN | - | WO2022066835A1 | PGDB_A040319 | PGDB_C019545 | PGDB_AS001252 | View |
| IC50 | - | = | 249 | nM | - | — | GSPT1 | - | NCI-H1155 | IL323841A | PGDB_A046200 | PGDB_C019545 | PGDB_AS002011 | View |
| EC50 | - | < | 1 | uM | - | — | GSPT1 | CRBN | HEK293 | WO2022066835A1 | PGDB_A046409 | PGDB_C019545 | PGDB_AS000168 | View |
| Kd | - | = | 9.9 | nM | - | — | CRBN | CRBN | HEK293 | IL323841A | PGDB_A050246 | PGDB_C019545 | PGDB_AS001216 | View |
| IC50 | - | = | 347 | nM | - | — | GSPT1 | - | HL-60 | IL323841A | PGDB_A061643 | PGDB_C019545 | PGDB_AS002473 | View |
| Dmax | - | = | 42.8 | % | Concentration series: 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 1 uM, 3 uM, 10 uM | 72 h | GSPT1 | - | HEK293 | IL323841A | PGDB_A067882 | PGDB_C019545 | PGDB_AS002464 | View |