PatGlueDB | Molecular Glue Patent Bioactivity Database

Target summary

Target IDPGDB_T000003

NameCCNK

Gene symbolCCNK

Protein nameCyclin-K

UniProt IDO75909

Roleassay_complex_component | degradation_target | neo_substrate | primary_target

Compounds617

Activity records1,271

Assays31

Patents10

Activity compounds and values

Activity records

1,271 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	2.25	uM	-	—	CCNK	-	MDA-MB-231	CN118955493	PGDB_A007027	PGDB_C006856	PGDB_AS001422	View
IC50	-	>	4	uM	-	—	CCNK	-	A549	CN118955493	PGDB_A007084	PGDB_C006862	PGDB_AS002241	View
GI50	-	<	1000	nM	-	—	CCNK	-	VCaP	WO2025245472A1	PGDB_A007095	PGDB_C012041	PGDB_AS001027	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	WO2021249517A1	PGDB_A007189	PGDB_C009524	PGDB_AS001569	View
GI50	-	<	1000	nM	-	—	CCNK	-	LNCaP	WO2025245472A1	PGDB_A007217	PGDB_C012025	PGDB_AS002467	View
DC50	-	<	500	nM	-	—	CCNK	-	-	WO2025245472A1	PGDB_A007298	PGDB_C012027	PGDB_AS001864	View
IC50	-	>	4	uM	-	—	CCNK	-	MDA-MB-231	CN118955493	PGDB_A007376	PGDB_C006875	PGDB_AS001422	View
DC50	-	>	10	uM	-	—	CCNK	-	-	AU2021359129A1	PGDB_A007396	PGDB_C019114	PGDB_AS000583	View
GI50	-	<	1000	nM	-	—	CCNK	-	VCaP	WO2025245472A1	PGDB_A007408	PGDB_C011998	PGDB_AS001027	View
IC50	-	=	188	nM	-	—	CCNK	-	COV362	CN120329284A	PGDB_A007569	PGDB_C006738	PGDB_AS002147	View
IC50	-	=	193	nM	-	—	CCNK	-	HGC-27	CN117946075A	PGDB_A007585	PGDB_C006709	PGDB_AS000524	View
DC50	-	>=	10	uM	-	—	CCNK	-	-	WO2021249517A1	PGDB_A007832	PGDB_C009593	PGDB_AS002455	View
GI50	-	>	3000	nM	-	—	CCNK	-	K562	WO2025245472A1	PGDB_A007844	PGDB_C011978	PGDB_AS000413	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	WO2021249517A1	PGDB_A007845	PGDB_C009497	PGDB_AS001569	View
IC50	-	=	48	nM	-	—	CCNK	-	NCI-N87	CN118206535A	PGDB_A007905	PGDB_C006764	PGDB_AS002215	View
IC50	-	>	4	uM	-	—	CCNK	-	HepG2	CN118955493	PGDB_A007972	PGDB_C006848	PGDB_AS001525	View
EC50	-	=	0.1-1	uM	-	—	CCNK	-	Hs-578T	WO2025104236	PGDB_A008011	PGDB_C010883	PGDB_AS000816	View
GI50	-	<	1000	nM	-	—	CCNK	-	VCaP	WO2025245472A1	PGDB_A008155	PGDB_C011987	PGDB_AS001027	View
GI50	-	>	3000	nM	-	—	CCNK	-	SH-SY5Y	WO2025245472A1	PGDB_A008237	PGDB_C012002	PGDB_AS000261	View
DC50	-	<	500	nM	-	—	CCNK	-	-	WO2025245472A1	PGDB_A008282	PGDB_C011995	PGDB_AS001864	View

Rows per pagePage 1 of 64 · 1,271 recordsGo to page