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Compound
PGDB_C000058
8 activity records4 related patents
2D structure
Cc1ccc(NC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1ClCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dmax | - | = | 92.5 | % | 10 uM | 20 h | GSPT1 | CRBN | HT-1080 | WO2022257897A1 | PGDB_A015056 | PGDB_C000058 | PGDB_AS000618 | View |
| % Degradation | - | = | 60-80 | % | 10 nM | 6 h | GSPT1 | - | MV-4-11 | CN120289428A | PGDB_A040627 | PGDB_C000058 | PGDB_AS000838 | View |
| DC50 | - | = | 0.653 | uM | - | — | CSNK1A1 | CRBN | HT-1080 | WO2022257897A1 | PGDB_A042422 | PGDB_C000058 | PGDB_AS001868 | View |
| Dmax | - | = | 53.7 | % | 10 uM | 20 h | CSNK1A1 | CRBN | HT-1080 | WO2022257897A1 | PGDB_A046628 | PGDB_C000058 | PGDB_AS000920 | View |
| IC50 | - | = | <= 3 | nM | - | — | GSPT1 | - | MV-4-11 | CN120289428A | PGDB_A059518 | PGDB_C000058 | PGDB_AS002456 | View |
| % Degradation | - | > | 99 | % | 20 uM | 24 h | IKZF1 | - | H929 | CN116457344A | PGDB_A075219 | PGDB_C000058 | PGDB_AS001367 | View |
| % Degradation | - | > | 99 | % | 10 uM | 24 h | IKZF1 | - | H929 | CN116457344A | PGDB_A077033 | PGDB_C000058 | PGDB_AS001613 | View |
| IC50 | - | = | 1.3 | nM | - | — | GSPT1 | - | SK-BR-3 | WO2025146129A1 | PGDB_A077717 | PGDB_C000058 | PGDB_AS000272 | View |