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Compound
PGDB_C000390
9 activity records3 related patents
2D structure
O=C1CCC(N2Cc3cc(O[C@H]4CCCC[C@@H]4N4CC(c5cccc(OC(F)(F)F)c5)C4)ccc3C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Degradation | - | = | 84.6 | % | 1 uM | 24 h | IKZF2 | - | HEK293T | US20230265071A1 | PGDB_A020094 | PGDB_C000390 | PGDB_AS000278 | View |
| EC50 | - | = | 0.017 | uM | - | — | CRBN | CRBN | HEK293T | CN117836288A | PGDB_A031163 | PGDB_C000390 | PGDB_AS001696 | View |
| EC50 | - | = | 0.017 | uM | - | — | IKZF2 | CRBN | HEK293T | AR126418A1 | PGDB_A032657 | PGDB_C000390 | PGDB_AS001328 | View |
| DC50 | - | > | 30 | uM | - | — | GSPT1 | - | HEK293T | AR126418A1 | PGDB_A044102 | PGDB_C000390 | PGDB_AS002212 | View |
| % Degradation | - | = | 84.6 | % | 1 uM | 24 h | IKZF2 | CRBN | HEK293T | CN117836288A | PGDB_A046915 | PGDB_C000390 | PGDB_AS002458 | View |
| DC50 | - | > | 30 | uM | - | — | GSPT1 | - | HEK293T | CN117836288A | PGDB_A058559 | PGDB_C000390 | PGDB_AS001378 | View |
| DC50 | - | > | 30 | uM | - | — | GSPT1 | - | HEK293T | US20230265071A1 | PGDB_A061214 | PGDB_C000390 | PGDB_AS000322 | View |
| EC50 | - | = | 0.017 | uM | - | — | CRBN | CRBN | - | US20230265071A1 | PGDB_A069927 | PGDB_C000390 | PGDB_AS001482 | View |
| % Degradation | - | = | 84.6 | % | 1 uM | 24 h | IKZF2 | CRBN | HEK293T | AR126418A1 | PGDB_A072150 | PGDB_C000390 | PGDB_AS000416 | View |