PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CN1CCn2c(cc3cc(-c4cccc(C5CCC(=O)NC5=O)c4Cl)ccc32)C1

Compound summary

Compound IDPGDB_C011096

FormulaC23H22ClN3O2

Molecular weight407.901

InChIKeyOKRVMFXYEUUGRJ-UHFFFAOYSA-N

Physicochemical properties

Exact mass407.1401

RDKit cLogP3.93

TPSA54.3

HBD / HBA1 / 4

Rotatable bonds2

Heavy atoms29

Hetero atoms6

Rings / aromatic5 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

25 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	25-75	%	100 nM	-	VAV1	-	Jurkat	WO2026061428A1	PGDB_A002234	PGDB_C011096	PGDB_AS000798	View
% Degradation	-	<	25	%	10 nM	-	-	-	Jurkat	WO2026061428A1	PGDB_A005950	PGDB_C011096	PGDB_AS001404	View
% Degradation	-	<	25	%	1 nM	-	VAV1	-	Jurkat	WO2026061428A1	PGDB_A005961	PGDB_C011096	PGDB_AS001791	View
% Degradation	-	<	25	%	1 nM	24 h	-	-	Jurkat	WO2026057000A1	PGDB_A008549	PGDB_C011096	PGDB_AS000238	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A010337	PGDB_C011096	PGDB_AS001961	View
Ymin	-	=	70.9	%	Concentration series: 1 uM, 10 uM	120 h	WEE1	-	MDA-MB-231	WO2025137053A1	PGDB_A014916	PGDB_C011096	PGDB_AS002525	View
DC50	-	=	9	nM	-	—	NEK7	-	CAL-51	WO2025024521A1	PGDB_A021873	PGDB_C011096	PGDB_AS001365	View
EC50	-	=	0.368	uM	-	—	WEE1	-	293T-LentiXWEE1-ePL	WO2025137053A1	PGDB_A023943	PGDB_C011096	PGDB_AS001798	View
EC50	-	=	0.15	uM	-	—	CRBN	CRBN	-	WO2025024521A1	PGDB_A024338	PGDB_C011096	PGDB_AS001033	View
% Degradation	-	>=	25	%	100 nM	24 h	-	-	Jurkat	CN121698875A	PGDB_A024889	PGDB_C011096	PGDB_AS000610	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A031712	PGDB_C011096	PGDB_AS002120	View
Ymin	-	=	30.7	%	Concentration series: 1 uM, 10 uM	4 h	WEE1	-	293T-LentiXWEE1-ePL	WO2025137053A1	PGDB_A032868	PGDB_C011096	PGDB_AS001848	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A033165	PGDB_C011096	PGDB_AS000431	View
CC50	-	>	1000	uM	-	—	14-3-3 sigma delta-C	-	-	US20230142739A1	PGDB_A036287	PGDB_C011096	PGDB_AS000437	View
% Degradation	-	<	25	%	10 nM	24 h	-	-	Jurkat	WO2026057000A1	PGDB_A045109	PGDB_C011096	PGDB_AS001993	View
Ymin	-	=	16.1	%	Concentration series: 1 uM, 10 uM	120 h	WEE1	-	MKN45	WO2025137053A1	PGDB_A046765	PGDB_C011096	PGDB_AS000997	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A047524	PGDB_C011096	PGDB_AS000900	View
% Degradation	-	<	25	%	1 nM	24 h	-	-	Jurkat	CN121698875A	PGDB_A048206	PGDB_C011096	PGDB_AS001370	View
EC50	-	=	1.555	uM	-	—	WEE1	-	MDA-MB-231	WO2025137053A1	PGDB_A051681	PGDB_C011096	PGDB_AS001832	View
% Degradation	-	>=	25	%	100 nM	24 h	-	-	Jurkat	WO2026057000A1	PGDB_A058958	PGDB_C011096	PGDB_AS001184	View

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