PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(c2cccc(-c3ccc4c(c3)cc3n4CCC3)c2Cl)C(=O)N1

Compound summary

Compound IDPGDB_C011097

FormulaC22H19ClN2O2

Molecular weight378.859

InChIKeyCOOQOKCWUTVQPQ-UHFFFAOYSA-N

Physicochemical properties

Exact mass378.1135

RDKit cLogP4.43

TPSA51.1

HBD / HBA1 / 3

Rotatable bonds2

Heavy atoms27

Hetero atoms5

Rings / aromatic5 / 3

Fraction Csp30.27

Formal charge0

Fragments1

Activity compounds and values

Activity records

21 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	25-75	%	100 nM	-	VAV1	-	Jurkat	WO2026061428A1	PGDB_A006047	PGDB_C011097	PGDB_AS000798	View
% Degradation	-	=	25-75	%	10 nM	-	-	-	Jurkat	WO2026061428A1	PGDB_A006460	PGDB_C011097	PGDB_AS001404	View
DC50	-	=	3	nM	-	—	NEK7	-	CAL-51	WO2025024521A1	PGDB_A008322	PGDB_C011097	PGDB_AS001365	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A010817	PGDB_C011097	PGDB_AS000900	View
EC50	-	=	0.053	uM	-	—	WEE1	-	MKN45	WO2025137053A1	PGDB_A016739	PGDB_C011097	PGDB_AS002043	View
Ymin	-	=	28.1	%	Concentration series: 1 uM, 10 uM	120 h	WEE1	-	MKN45	WO2025137053A1	PGDB_A019038	PGDB_C011097	PGDB_AS000997	View
% Degradation	-	<	25	%	1 nM	24 h	-	-	Jurkat	CN121698875A	PGDB_A021451	PGDB_C011097	PGDB_AS001370	View
EC50	-	=	0.234	uM	-	—	WEE1	-	MDA-MB-231	WO2025137053A1	PGDB_A024189	PGDB_C011097	PGDB_AS001832	View
Dmax	-	=	94	%	Concentration series: 1 uM, 0.05 nM	24 h	NEK7	-	CAL-51	WO2025024521A1	PGDB_A026395	PGDB_C011097	PGDB_AS002061	View
% Degradation	-	>=	25	%	10 nM	24 h	-	-	Jurkat	CN121698875A	PGDB_A028691	PGDB_C011097	PGDB_AS000715	View
% Degradation	-	>=	25	%	100 nM	24 h	-	-	Jurkat	CN121698875A	PGDB_A031878	PGDB_C011097	PGDB_AS000610	View
CC50	-	=	200	uM	-	—	14-3-3 sigma delta-C	-	-	US20230142739A1	PGDB_A033806	PGDB_C011097	PGDB_AS000437	View
EC50	-	=	0.11	uM	-	—	CRBN	CRBN	-	WO2025024521A1	PGDB_A051832	PGDB_C011097	PGDB_AS001033	View
EC50	-	=	0.339	uM	-	—	WEE1	-	293T-LentiXWEE1-ePL	WO2025137053A1	PGDB_A056537	PGDB_C011097	PGDB_AS001798	View
Ymin	-	=	73.8	%	Concentration series: 1 uM, 10 uM	120 h	WEE1	-	MDA-MB-231	WO2025137053A1	PGDB_A056734	PGDB_C011097	PGDB_AS002525	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A059330	PGDB_C011097	PGDB_AS002120	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A059818	PGDB_C011097	PGDB_AS000431	View
Kd	-	=	9.09	uM	-	—	-	-	-	US20230142739A1	PGDB_A065528	PGDB_C011097	PGDB_AS000811	View
Ymin	-	=	33.4	%	Concentration series: 1 uM, 10 uM	4 h	WEE1	-	293T-LentiXWEE1-ePL	WO2025137053A1	PGDB_A074064	PGDB_C011097	PGDB_AS001848	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A075505	PGDB_C011097	PGDB_AS001961	View

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