PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCN(c5cccc6sccc56)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019176

FormulaC26H26N4O3S

Molecular weight474.586

InChIKeyYNQIGCDEZOCFRG-UHFFFAOYSA-N

Physicochemical properties

Exact mass474.1726

RDKit cLogP2.98

TPSA73

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms34

Hetero atoms8

Rings / aromatic6 / 3

Fraction Csp30.35

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	10-50	nM	-	—	IKZF3	-	MGC-803	WO2025016359A1	PGDB_A015575	PGDB_C019176	PGDB_AS001973	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	CCRF-CEM	WO2025016359A1	PGDB_A016498	PGDB_C019176	PGDB_AS000461	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A026185	PGDB_C019176	PGDB_AS000700	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A026961	PGDB_C019176	PGDB_AS000690	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A029327	PGDB_C019176	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A035601	PGDB_C019176	PGDB_AS002547	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A037036	PGDB_C019176	PGDB_AS001897	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	SW620	WO2025016359A1	PGDB_A040584	PGDB_C019176	PGDB_AS001811	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A041817	PGDB_C019176	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A050847	PGDB_C019176	PGDB_AS001760	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A053244	PGDB_C019176	PGDB_AS000926	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A053266	PGDB_C019176	PGDB_AS002465	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A070926	PGDB_C019176	PGDB_AS000262	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	VCaP	WO2025016359A1	PGDB_A073149	PGDB_C019176	PGDB_AS000687	View

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