PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1ccc(Sc2ccccc2N2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)c(C)c1

Compound summary

Compound IDPGDB_C019177

FormulaC32H34N4O3S

Molecular weight554.716

InChIKeyJVIBNJQICQZTRD-UHFFFAOYSA-N

Physicochemical properties

Exact mass554.2352

RDKit cLogP4.54

TPSA73

HBD / HBA1 / 6

Rotatable bonds6

Heavy atoms40

Hetero atoms8

Rings / aromatic6 / 3

Fraction Csp30.34

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A016177	PGDB_C019177	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A021958	PGDB_C019177	PGDB_AS001760	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MGC-803	WO2025016359A1	PGDB_A023968	PGDB_C019177	PGDB_AS001973	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A030356	PGDB_C019177	PGDB_AS000690	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	VCaP	WO2025016359A1	PGDB_A036128	PGDB_C019177	PGDB_AS000687	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	TMD8	WO2025016359A1	PGDB_A037116	PGDB_C019177	PGDB_AS000926	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A043695	PGDB_C019177	PGDB_AS000262	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	SW620	WO2025016359A1	PGDB_A053864	PGDB_C019177	PGDB_AS001811	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A053879	PGDB_C019177	PGDB_AS000700	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A054700	PGDB_C019177	PGDB_AS001897	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	CCRF-CEM	WO2025016359A1	PGDB_A055825	PGDB_C019177	PGDB_AS000461	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A056797	PGDB_C019177	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A067326	PGDB_C019177	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A070365	PGDB_C019177	PGDB_AS000593	View

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