PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCN(c5cccc(Cl)c5Cl)CC4)cc(F)c3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019188

FormulaC24H23Cl2FN4O3

Molecular weight505.377

InChIKeyAAKKIWPIDZHNRA-UHFFFAOYSA-N

Physicochemical properties

Exact mass504.1131

RDKit cLogP3.22

TPSA73

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms34

Hetero atoms10

Rings / aromatic5 / 2

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

18 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	50-100	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A010415	PGDB_C019188	PGDB_AS000939	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	SR	WO2025016359A1	PGDB_A012473	PGDB_C019188	PGDB_AS002046	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A014554	PGDB_C019188	PGDB_AS000593	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A018752	PGDB_C019188	PGDB_AS000690	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	VCaP	WO2025016359A1	PGDB_A019424	PGDB_C019188	PGDB_AS000687	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A020300	PGDB_C019188	PGDB_AS001760	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A030712	PGDB_C019188	PGDB_AS001647	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MGC-803	WO2025016359A1	PGDB_A036014	PGDB_C019188	PGDB_AS001973	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A037359	PGDB_C019188	PGDB_AS000537	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	MM.1R	WO2025016359A1	PGDB_A039898	PGDB_C019188	PGDB_AS001084	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A042301	PGDB_C019188	PGDB_AS000262	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A045805	PGDB_C019188	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A052279	PGDB_C019188	PGDB_AS002465	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	CCRF-CEM	WO2025016359A1	PGDB_A052575	PGDB_C019188	PGDB_AS000461	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A061592	PGDB_C019188	PGDB_AS002547	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A062231	PGDB_C019188	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A076933	PGDB_C019188	PGDB_AS000700	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	SW620	WO2025016359A1	PGDB_A077397	PGDB_C019188	PGDB_AS001811	View

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