PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

COc1cccc(N2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)c1

Compound summary

Compound IDPGDB_C019191

FormulaC25H28N4O4

Molecular weight448.523

InChIKeyVPKVQXYILRUAFR-UHFFFAOYSA-N

Physicochemical properties

Exact mass448.2111

RDKit cLogP1.78

TPSA82.2

HBD / HBA1 / 6

Rotatable bonds5

Heavy atoms33

Hetero atoms8

Rings / aromatic5 / 2

Fraction Csp30.4

Formal charge0

Fragments1

Activity compounds and values

Activity records

18 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	10-50	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A014108	PGDB_C019191	PGDB_AS000262	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	SW620	WO2025016359A1	PGDB_A021857	PGDB_C019191	PGDB_AS001811	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A022841	PGDB_C019191	PGDB_AS002547	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A025413	PGDB_C019191	PGDB_AS001975	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A027014	PGDB_C019191	PGDB_AS000593	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	MM.1R	WO2025016359A1	PGDB_A033307	PGDB_C019191	PGDB_AS001084	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A039095	PGDB_C019191	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A039318	PGDB_C019191	PGDB_AS001760	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A039917	PGDB_C019191	PGDB_AS000537	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A044556	PGDB_C019191	PGDB_AS000700	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MGC-803	WO2025016359A1	PGDB_A044817	PGDB_C019191	PGDB_AS001973	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A049904	PGDB_C019191	PGDB_AS000690	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A060754	PGDB_C019191	PGDB_AS000939	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A062952	PGDB_C019191	PGDB_AS001647	View
IC50	-	=	1-1.5	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A063477	PGDB_C019191	PGDB_AS001897	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	SR	WO2025016359A1	PGDB_A069629	PGDB_C019191	PGDB_AS002046	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	CCRF-CEM	WO2025016359A1	PGDB_A071402	PGDB_C019191	PGDB_AS000461	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	VCaP	WO2025016359A1	PGDB_A075081	PGDB_C019191	PGDB_AS000687	View

Rows per pagePage 1 of 1 · 18 recordsGo to page