PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCC(c5cccc(C(F)(F)F)c5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019204

FormulaC26H26F3N3O3

Molecular weight485.506

InChIKeyVYNPWSFMNYEZKQ-UHFFFAOYSA-N

Physicochemical properties

Exact mass485.1926

RDKit cLogP3.85

TPSA69.7

HBD / HBA1 / 4

Rotatable bonds4

Heavy atoms35

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.42

Formal charge0

Fragments1

Activity compounds and values

Activity records

18 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A013576	PGDB_C019204	PGDB_AS001647	View
IC50	-	=	1-5	nM	-	—	IKZF3	-	Jurkat	WO2025016359A1	PGDB_A016197	PGDB_C019204	PGDB_AS000690	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	SR	WO2025016359A1	PGDB_A020408	PGDB_C019204	PGDB_AS002046	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	H1975	WO2025016359A1	PGDB_A028233	PGDB_C019204	PGDB_AS000939	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	MOLT-4	WO2025016359A1	PGDB_A030617	PGDB_C019204	PGDB_AS001975	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	VCaP	WO2025016359A1	PGDB_A034385	PGDB_C019204	PGDB_AS000687	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A035872	PGDB_C019204	PGDB_AS000700	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	SW620	WO2025016359A1	PGDB_A036714	PGDB_C019204	PGDB_AS001811	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MGC-803	WO2025016359A1	PGDB_A036870	PGDB_C019204	PGDB_AS001973	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A053466	PGDB_C019204	PGDB_AS000593	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	CCRF-CEM	WO2025016359A1	PGDB_A056334	PGDB_C019204	PGDB_AS000461	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A063030	PGDB_C019204	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A064005	PGDB_C019204	PGDB_AS002547	View
IC50	-	=	5-10	nM	-	—	IKZF3	-	MM.1R	WO2025016359A1	PGDB_A065557	PGDB_C019204	PGDB_AS001084	View
IC50	-	=	10-50	nM	-	—	IKZF3	-	CAL-62	WO2025016359A1	PGDB_A066623	PGDB_C019204	PGDB_AS000262	View
IC50	-	=	0.5-1	uM	-	—	CRBN	CRBN	-	WO2025016359A1	PGDB_A068865	PGDB_C019204	PGDB_AS001897	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A070667	PGDB_C019204	PGDB_AS002465	View
IC50	-	=	100-500	nM	-	—	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A072694	PGDB_C019204	PGDB_AS000537	View

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