PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C[C@](O)(CNc1ccc(C#N)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1

Compound summary

Compound IDPGDB_C025999

FormulaC19H15F3N4O2

Molecular weight388.349

InChIKeyPKAHJOQGZSAKCR-SFHVURJKSA-N

Physicochemical properties

Exact mass388.1147

RDKit cLogP3.25

TPSA108.9

HBD / HBA3 / 5

Rotatable bonds5

Heavy atoms28

Hetero atoms9

Rings / aromatic2 / 2

Fraction Csp30.21

Formal charge0

Fragments1

Activity compounds and values

Activity records

39 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	<=	50	nM	-	—	VAV1	-	Jurkat	WO2026061428A1	PGDB_A001694	PGDB_C025999	PGDB_AS001390	View
Dmax	-	=	62	%	-	24 h	IKZF1	-	Jurkat	WO2026080794A1	PGDB_A004650	PGDB_C025999	PGDB_AS000804	View
Dmax	-	=	92	%	-	24 h	IKZF2	-	Jurkat	WO2026080794A1	PGDB_A004871	PGDB_C025999	PGDB_AS000354	View
Dmax	-	=	69	%	-	24 h	IKZF3	-	Jurkat	WO2026080794A1	PGDB_A004885	PGDB_C025999	PGDB_AS000982	View
DC50	-	=	301	nM	-	—	IKZF3	-	Jurkat	WO2026080794A1	PGDB_A006930	PGDB_C025999	PGDB_AS000910	View
Emax	-	=	24.8	%	-	-	-	-	-	JP2018513179A	PGDB_A009037	PGDB_C025999	PGDB_AS000006	View
% Inhibition	-	=	20.9	%	1 uM	-	-	-	-	JP2018513179A	PGDB_A010923	PGDB_C025999	PGDB_AS000345	View
IC50	-	>	1000	nM	-	—	-	-	-	JP2018513179A	PGDB_A011650	PGDB_C025999	PGDB_AS000864	View
EC50	-	=	626	nM	-	—	-	-	-	JP2018513179A	PGDB_A013517	PGDB_C025999	PGDB_AS001614	View
IC50	-	=	119	nM	-	—	-	-	-	JP2018513179A	PGDB_A013892	PGDB_C025999	PGDB_AS000680	View
Ymin	-	=	79.6	%	Concentration series: 1 uM, 10 uM	120 h	WEE1	-	MDA-MB-231	WO2025137053A1	PGDB_A013921	PGDB_C025999	PGDB_AS002525	View
EC50	-	=	2.718	uM	-	—	WEE1	-	MDA-MB-231	WO2025137053A1	PGDB_A016792	PGDB_C025999	PGDB_AS001832	View
DC50	-	>	5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A024018	PGDB_C025999	PGDB_AS000431	View
Kd	-	=	0.007	uM	-	—	CRBN	CRBN	-	EP3556760A1	PGDB_A024556	PGDB_C025999	PGDB_AS000988	View
IC50	-	>	500	nM	-	—	CRBN	CRBN	-	WO2022219412A1	PGDB_A025438	PGDB_C025999	PGDB_AS000438	View
EC50	-	=	0.0023	uM	-	—	WEE1	-	LentiX-oeWEE1-ePL	WO2026030657A1	PGDB_A028929	PGDB_C025999	PGDB_AS000951	View
EC50	-	=	0.0001	uM	-	—	WEE1	-	MKN45	WO2026030657A1	PGDB_A031245	PGDB_C025999	PGDB_AS002574	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A033147	PGDB_C025999	PGDB_AS002120	View
EC50	-	=	47	nM	-	—	-	-	-	JP2018513179A	PGDB_A033971	PGDB_C025999	PGDB_AS002549	View
EC50	-	=	0.337	uM	-	—	WEE1	-	MKN45	WO2025137053A1	PGDB_A035016	PGDB_C025999	PGDB_AS002043	View

Rows per pagePage 1 of 2 · 39 recordsGo to page