PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN116239566A

AssigneeGluetacs Therapeutics Shanghai

TitleE3 ubiquitin ligase ligand compound, protein degradation agent developed based on the ligand compound and their applications

Family ID86630402

Family members8

Filing year2022

Publication date2023-06-09

JurisdictionCN

Compounds202

Activity records833

Assays140

Activity compounds and values

Activity records

833 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	<	50	nM	-	—	BTK	-	MDA-MB-231	PGDB_A007072	PGDB_C025809	PGDB_AS001770	View
IC50	-	=	50-100	nM	-	—	-	-	SU-DHL-4	PGDB_A007090	PGDB_C025931	PGDB_AS000122	View
IC50	-	<	50	nM	-	—	PTK2	-	CAL-62	PGDB_A007313	PGDB_C019620	PGDB_AS000002	View
IC50	-	<	50	nM	-	—	-	-	Kasumi-1	PGDB_A007362	PGDB_C025929	PGDB_AS002344	View
IC50	-	=	100-500	nM	-	—	-	-	Hep3B2.7-1	PGDB_A007478	PGDB_C025928	PGDB_AS001723	View
IC50	-	<	50	nM	-	—	ABL1	-	Kasumi-1	PGDB_A007508	PGDB_C025886	PGDB_AS000069	View
IC50	-	=	100-500	nM	-	—	PTK2	-	CAL-62	PGDB_A007522	PGDB_C019625	PGDB_AS000002	View
IC50	-	=	100-500	nM	-	—	-	-	Kasumi-1	PGDB_A007598	PGDB_C025928	PGDB_AS002344	View
IC50	-	>	10000	nM	-	—	PTPN11	-	Ramos	PGDB_A007612	PGDB_C025828	PGDB_AS000678	View
IC50	-	<	50	nM	-	—	EGFR	-	PC-9	PGDB_A007776	PGDB_C025835	PGDB_AS000044	View
IC50	-	=	100-500	nM	-	—	IRAK4	-	MV-4-11	PGDB_A007813	PGDB_C025977	PGDB_AS000709	View
IC50	-	<	50	nM	-	—	ESR1	-	SW620	PGDB_A007820	PGDB_C019594	PGDB_AS001305	View
IC50	-	=	1000-5000	nM	-	—	PTK2	-	VCaP	PGDB_A007856	PGDB_C019620	PGDB_AS000495	View
IC50	-	>	10000	nM	-	—	PTPN11	-	Ramos	PGDB_A007917	PGDB_C025832	PGDB_AS000678	View
IC50	-	<	50	nM	-	—	PTK2	-	Mino	PGDB_A007953	PGDB_C025942	PGDB_AS000370	View
IC50	-	=	50-100	nM	-	—	EGFR	-	PC-9	PGDB_A007990	PGDB_C025840	PGDB_AS000044	View
IC50	-	<	50	nM	-	—	-	-	Kasumi-1	PGDB_A008115	PGDB_C025930	PGDB_AS002344	View
IC50	-	=	100-500	nM	-	—	IRAK4	-	SU-DHL-4	PGDB_A008343	PGDB_C025971	PGDB_AS002569	View
IC50	-	<	50	nM	-	—	ABL1	-	K562	PGDB_A008498	PGDB_C025890	PGDB_AS002026	View
IC50	-	<	50	nM	-	—	BTK	-	Kasumi-1	PGDB_A008646	PGDB_C025806	PGDB_AS000510	View

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