PatGlueDB | Molecular Glue Patent Bioactivity Database

Target summary

Target IDPGDB_T000105

NameCDK12

Gene symbolCDK12

Protein nameCyclin-dependent kinase 12

UniProt IDQ9NYV4

Roleprimary_target

Compounds255

Activity records404

Assays12

Patents5

Activity compounds and values

Activity records

404 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	18	nM	-	—	CDK12	-	-	CN114929708B	PGDB_A007206	PGDB_C006612	PGDB_AS001268	View
IC50	-	=	37	nM	-	—	CDK12	-	-	CN114929708B	PGDB_A007534	PGDB_C006595	PGDB_AS001268	View
IC50	-	<=	0.1	uM	-	—	CDK12	-	-	WO2025110815A1	PGDB_A007735	PGDB_C010941	PGDB_AS002095	View
IC50	-	=	0.85	nM	-	—	CDK12	-	MDA-MB-231	CN120590389A	PGDB_A008020	PGDB_C007314	PGDB_AS000401	View
IC50	-	=	30.35	nM	-	—	CDK12	-	MDA-MB-231	CN121108130A	PGDB_A008061	PGDB_C007331	PGDB_AS001069	View
IC50	-	=	253	nM	-	—	CDK12	-	-	CN114929708B	PGDB_A008142	PGDB_C006566	PGDB_AS001187	View
IC50	-	=	19.37	nM	-	—	CDK12	-	-	CN121108130A	PGDB_A008223	PGDB_C007326	PGDB_AS002060	View
IC50	-	=	57.46	nM	-	—	CDK12	-	-	CN121108130A	PGDB_A008550	PGDB_C007335	PGDB_AS002060	View
IC50	-	=	100	nM	-	—	CDK12	-	-	CN114929708B	PGDB_A008731	PGDB_C006609	PGDB_AS001268	View
IC50	-	=	1.6	nM	-	—	CDK12	-	A673	CN114929708B	PGDB_A008825	PGDB_C006594	PGDB_AS002570	View
IC50	-	>	10000	nM	-	—	CDK12	-	MDA-MB-468	CN121108130A	PGDB_A009020	PGDB_C007327	PGDB_AS000556	View
IC50	-	=	209.9	nM	-	—	CDK12	-	MDA-MB-231	CN120590389A	PGDB_A009306	PGDB_C007293	PGDB_AS000401	View
IC50	-	=	385.8	nM	-	—	CDK12	-	MDA-MB-231	CN120590389A	PGDB_A009397	PGDB_C007310	PGDB_AS000401	View
IC50	-	=	21.45	nM	-	—	CDK12	-	MDA-MB-468	CN120590389A	PGDB_A009502	PGDB_C007266	PGDB_AS000658	View
IC50	-	=	236.6	nM	-	—	CDK12	-	MDA-MB-231	CN120590389A	PGDB_A010021	PGDB_C007252	PGDB_AS000401	View
IC50	-	=	0.37	nM	-	—	CDK12	-	MDA-MB-231	CN120590389A	PGDB_A010256	PGDB_C007253	PGDB_AS000401	View
IC50	-	=	0.03	nM	-	—	CDK12	-	MDA-MB-468	CN120590389A	PGDB_A010315	PGDB_C007253	PGDB_AS000658	View
IC50	-	>	0.5	uM	-	—	CDK12	-	-	WO2025110815A1	PGDB_A010380	PGDB_C010927	PGDB_AS002095	View
IC50	-	<=	0.1	uM	-	—	CDK12	-	-	WO2025110815A1	PGDB_A010555	PGDB_C010962	PGDB_AS002095	View
IC50	-	=	46	nM	-	—	CDK12	-	-	CN114929708B	PGDB_A010565	PGDB_C006608	PGDB_AS001187	View

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