PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2019200310A1

AssigneeFred Hutchinson Cancer Center, Scripps Research Institute, University Of Washington

TitleE3 ubiquitin ligase agonists, pharmaceutical compositions including the e3 ubiquitin ligase agonists, related methods of use

Family ID68163863

Family members3

Filing year2019

Publication date2019-10-17

JurisdictionWO

Compounds62

Activity records528

Assays9

Activity compounds and values

Activity records

528 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
EC50	-	=	0.0000000089	M	-	—	CYCEP	-	-	PGDB_A007025	PGDB_C019895	PGDB_AS001078	View
EC50	-	=	0.0000142	M	-	—	FBXW7	-	-	PGDB_A007266	PGDB_C019882	PGDB_AS002126	View
EC50	-	=	0.0000022	M	-	—	FBXW7	-	-	PGDB_A007401	PGDB_C021159	PGDB_AS002126	View
EC50	-	=	0.0000127	M	-	—	FBXW7	-	-	PGDB_A007442	PGDB_C019915	PGDB_AS000046	View
EC50	-	=	0.0000653	M	-	—	FBXW7	-	-	PGDB_A007624	PGDB_C019896	PGDB_AS001009	View
EC50	-	=	0.0000000032	M	-	—	FBXW7	-	-	PGDB_A007727	PGDB_C019897	PGDB_AS000046	View
EC50	-	=	0.0000754	M	-	—	FBXW7	-	-	PGDB_A008024	PGDB_C019868	PGDB_AS001009	View
EC50	-	=	0.0000000001318	M	-	—	FBXW7	-	-	PGDB_A008072	PGDB_C019883	PGDB_AS002126	View
EC50	-	=	0.0000196	M	-	—	FBXW7	-	-	PGDB_A008208	PGDB_C019880	PGDB_AS000046	View
Dmax	-	=	8.63	%	Concentration context: 65.3E-6	-	FBXW7	-	-	PGDB_A008227	PGDB_C019904	PGDB_AS001280	View
EC50	-	=	0.0000000203	M	-	—	FBXW7	-	-	PGDB_A008602	PGDB_C019887	PGDB_AS002126	View
EC50	-	=	0.0000653	M	-	—	FBXW7	-	-	PGDB_A008738	PGDB_C019889	PGDB_AS001009	View
EC50	-	=	0.0000715	M	-	—	FBXW7	-	-	PGDB_A008763	PGDB_C019874	PGDB_AS000046	View
EC50	-	=	0.000002	M	-	—	CYCEP	-	-	PGDB_A008783	PGDB_C019911	PGDB_AS001078	View
EC50	-	=	0.0000593	M	-	—	FBXW7	-	-	PGDB_A009057	PGDB_C019914	PGDB_AS002246	View
EC50	-	=	0.0000164	M	-	—	FBXW7	-	-	PGDB_A009201	PGDB_C019894	PGDB_AS002126	View
EC50	-	=	0.0000000903	M	-	—	FBXW7	-	-	PGDB_A009207	PGDB_C019917	PGDB_AS000046	View
EC50	-	=	0.0000241	M	-	—	FBXW7	-	-	PGDB_A009333	PGDB_C019900	PGDB_AS002126	View
EC50	-	=	0.0000238	M	-	—	FBXW7	-	-	PGDB_A009365	PGDB_C019903	PGDB_AS000046	View
Dmax	-	=	0.18	%	-	-	FBXW7	-	-	PGDB_A009592	PGDB_C019919	PGDB_AS000856	View

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